Best Top-level domains you can buy, if the .com is taken
What is in your opinion the second best top level domain if the .com is already taken?
To answer my own question, I would say none. No other TLD is better than .com, especially on the long run. Your website will have a much bigger value if you were to sell it at some point of you have a .com
If the .com is taken, look and search for another .com domain name. Trust me, there are plenty of untaken ideas out there.
.net may be the only ones I would consider. Along with .info for very small and micro-niched content.